Sex steroid binding to human lymphocytes plasma membrane
نویسندگان
چکیده
منابع مشابه
Identification of lysine 134 in the steroid-binding site of the sex steroid-binding protein of human plasma.
The sex steroid-binding protein of human plasma SBP (or sex hormone-binding globulin, SHBG) was specifically inhibited with the alkylating affinity label, 17 beta-[[( 2-14C]bromoacetyl)oxy]-5 alpha-androstan-3-one. The natural ligand, 5 alpha-dihydrotestosterone, was shown to protect against inactivation and labeling. The steroid-binding activity of the protein was abolished when approximately ...
متن کاملRadioimmunoassay of testosterone not bound to sex-steroid-binding protein in plasma.
To measure the concentration of testosterone (T) that is not bound to sex-steroid-binding protein (SBP) in plasma, we quantified by radioimmunoassay the T in the supernates of plasma samples after precipitation with 50%-saturated ammonium sulfate. The concentrations of non-SBP-bound T. directly measured with this assay, correlated significantly (P less than 0.001) with those deduced from measur...
متن کاملtudy on sex steroid-binding proteins (with emphasize on 17 -estradiol) in plasma of female and juvenile kutum (Rutilus frisii kutum)
A sex steroid-binding protein (SBP) that binds to 17 b-estradiol with high affinity and moderate capacity was identified in the plasma of female and juvenile of kutum (Rutilus frisii kutum) sampled during the early stage of gonadal maturation in October and prior to spawning in March. Mean maximum specific binding (Bmax) and equilibrium dissociation constant (Kd) of the fish were as follows: In...
متن کاملtudy on sex steroid-binding proteins (with emphasize on 17 -estradiol) in plasma of female and juvenile kutum (Rutilus frisii kutum)
A sex steroid-binding protein (SBP) that binds to 17 b-estradiol with high affinity and moderate capacity was identified in the plasma of female and juvenile of kutum (Rutilus frisii kutum) sampled during the early stage of gonadal maturation in October and prior to spawning in March. Mean maximum specific binding (Bmax) and equilibrium dissociation constant (Kd) of the fish were as follows: In...
متن کاملPlasma steroid-binding proteins: primary gatekeepers of steroid hormone action
Biologically active steroids are transported in the blood by albumin, sex hormone-binding globulin (SHBG), and corticosteroid-binding globulin (CBG). These plasma proteins also regulate the non-protein-bound or 'free' fractions of circulating steroid hormones that are considered to be biologically active; as such, they can be viewed as the 'primary gatekeepers of steroid action'. Albumin binds ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1984
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1984.81